Talk about biology live broadcast: Dr. Wang Ziyuan, a lake view biology, exploring hepatitis B with gene therapy

Hepatitis B , Hepatitis B for short , It is a hepatitis B virus （HBV） Diseases caused by infection . Hepatitis B virus is a hepatophilic virus , It mainly exists in hepatocytes and damages hepatocytes , Infection with hepatitis B causes inflammation. 、 Fibrosis 、 Liver cirrhosis and even liver cancer . Hepatitis B is divided into acute and chronic . Acute hepatitis B in adults 90% Self healing , The manifestations of chronic hepatitis B are different , Chronic hepatitis B carriers 、 Chronic active hepatitis B 、 Hepatitis B cirrhosis . There are about 80% HCC comes from patients with chronic hepatitis B virus. .

Development of hepatitis B drugs

Currently, the treatment of hepatitis B includes nucleoside analogues and interferon. , Functional cure can be achieved ; But to prevent hepatitis B recurrence or exacerbation of the purpose. , Elimination of hepatitis B virus cccDN, Radical cure of chronic hepatitis B . The main challenge facing the development of radical hepatitis B is how to eliminate it. cccDNA（ Covalent closed loop formed by hepatitis B virus entering human genome DNA Stable form of ）、 Targeting viral genome and overcoming immune barriers . Hepatitis B virus is not listed in the listed hepatitis B virus. cccDNA Designed as a target , Can only lower HBsAg And viruses DNA level , It's hard to clean it up completely cccDNA, Therefore, it is easy to relapse after drug withdrawal , There is an urgent need to develop a radical cure （ eliminate cccDNA） New hepatitis B drugs .

Gene therapy for hepatitis B & Lake life

If you can cure hepatitis B , Not only can eliminate the pain and burden of hepatitis B patients' life. , It can also cut off the root cause of liver cancer at the same time , Objective to reduce the incidence of liver cancer . The emerging gene therapy technology has brought hope to cure hepatitis B completely. . Gene therapy vector can carry biological drugs with nuclease activity into the infected liver nucleus , Targeted degradation of hepatitis B virus cccDNA, Achieve the goal of curing hepatitis B . This will be a dividend for patients brought by the development of the times , It has great social significance and economic value .

Research interests focus on common 、 One of the key aspects of lakeside biopharmaceuticals in the treatment of major diseases is the establishment of a platform for HBV gene therapy. , The aim is to cure hepatitis B. , At the same time, cut off the root cause of liver cancer , Indirectly reduce the incidence of liver cancer , Benefit society . eliminate cccDNA, Gene therapy for hepatitis B is also the founder of Lake vision biopharmaceutical. 、 Chief scientist Dr. Wang Ziyuan is one of the key research directions .

# Talk about the live broadcast of biological medicine #

Focus on hepatitis B gene therapy , Organized by Tansi Biology T-Bio Tan Si biological medicine live broadcast textbook specially invited to Founder of Hujing biopharmaceutical , Chief scientist Dr. Wang Ziyuan stay 4 month 27 Japan 19:30-20:30 To bring you “ Exploration of gene therapy for hepatitis B eradication ” The wonderful sharing of . Dr. Wang Ziyuan will introduce the latest stage of hepatitis B treatment with listeners. 、 Cure the key and signs, and two key problems to be solved by gene therapy for hepatitis B eradication. , Coming soon .

# Guest profile #

Dr. Wang Ziyuan

Wang Ziyuan , Lake View （ Suzhou ） Founder of biopharmaceutical Co., Ltd , Chief scientist .1984 Graduated from Shanxi University in , On 1989 Annual study in Germany , He received his master's degree in biology and his doctor's degree in molecular genetics from the University of Constance and the University of Cologne, respectively . Then at Heidelberg University School of medicine 、 Five years at the medical school of Gottingen University .2004 Return to China in 2000 ,2021 year 9 Lake View （ Suzhou ） Biopharmaceutical Co., Ltd .

# Live time #

4 month 27 Japan 19:30-20:30

# Speech theme #

Exploration of gene therapy for hepatitis B eradication

# Topic highlights #

1. After more than 40 years of efforts , Now, hepatitis B has reached a stage of functional cure. .

2. Intrahepatic spiral closure cccDNA The existence of , Is the root cause of hepatitis B infection and recurrence. . Clear up hepatitis B virus cccDNA Is the key and sign of cure .

3. The rapid development of gene therapy technology has opened the way for eradication of hepatitis B. . Two key problems in gene therapy for hepatitis B ：① How to use gene editing tools to cut hepatitis B accurately cccDNA;② How to target and efficiently deliver gene editing tools to hepatocytes .