Magnetic Core-Shell Fe3O4 Particles Supported Gold Nanostars | Magnetic Fe3O4-POSS-COOH | Superparamagnetic Fe3O4-Polydopamine Core-Shell Nanoparticles

Magnetic core-shell Fe3O4 particles loaded with gold nanostars|magnetic Fe3O4-POSS-COOH|superparamagnetic Fe3O4-polydopamine core-shell nanoparticles

In this paper, a chemically modified doxorubicin prodrug containing sulfhydryl and acylhydrazone bonds was prepared by covalentNanoparticles were loaded onto nanoparticles to prepare a drug-controlled release system with pH stimulus responsive properties and potential properties of magnetothermal therapy, magnetic targeting and magnetic resonance imaging. Ferric oxide nanoparticles were prepared by polyol high-temperature pyrolysis,Its structure and composition were characterized by dynamic light scattering, transmission electron microscopy, X-ray diffraction, Fourier transform infrared spectroscopy and other detection methods. The FeO nanoparticles have uniform particle size distribution and good dispersion stability in water.Its size is smaller than the critical value of single domain, and its superparamagnetic and high magnetic saturation strength is proved by the magnetic hysteresis loop. The polydopamine nanoparticles and superparamagnetic iron tetroxide were synthesized by the self-polymerization of dopamine under alkaline conditions.Polydopamine core-shell structure nanoparticles are two carriers. The results show that the core-shell structure polydopamine tetroxide nanoparticles also have superparamagnetic properties and good magnetic response ability. The polydopamine can be adjusted by controlling the alkalinity of the reaction solution.The particle size of the nanoparticles can be synthesized to meet the requirements of in vivo applications. The results of thermogravimetric analysis show that the content of ferric tetroxide is about 5%.Doxorubicin prodrugs with acylhydrazone bonds. Doxorubicin prodrugs are loaded onto nanoparticle surfaces by Michael addition reaction between sulfhydryl and catechol groups under oxygen and alkaline conditions. Transmission Electron Microscopy, DynamicsLight scattering test showed that the structure and morphology of nanoparticles remained unchanged before and after drug loading

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Qi Yue Xiaobian axc.23022.08.08