The Biotin-PEG3-Br/acid/NHS ester/alcohol/amine collection that everyone wants to share

Biotin-biotin is widely used in daily life. The chemical structure of biotin includes a fusiyl side chain containing five carbon atoms and two five-membered heterocycles. In general,, Biotin is quite stable and will only be destroyed when treated with strong acid, alkali, formaldehyde and ultraviolet rays.Therefore, by connecting with PEG, it can be connected with compounds containing functional groups such as carboxylic acid, active ester, amine, etc. For some of their specific characteristics, let's learn from the sharing below of Xi'an Kaixin Bio!

I. Biotin-PEG3-Br

CAS No: 1041766-91-9|English Name: Biotin-PEG3-Br|Chinese Name: Biotin-Tripolyethylene Glycol-Bromo|Molecular Weight: 482.43|Molecular Formula: C18H32BrN3O5S

Second, Biotin-PEG3-acid

CAS No.: 252881-76-8|English name: Biotin-PEG3-acid|Chinese name: Biotin-PEG3-carboxylic acid|Molecular weight: 544.6|Molecular formula: C23H36N4O9S

Characteristics: Biotin-PEG3-carboxylic acid is a biotinylating reagent that reacts with amine attachment molecules.PEG linked to biotin provides an extended spacer arm that allows biotin to enter the binding pocket of a protein or macromolecule.

Third, Biotin-PEG3-NHS ester

CAS No.: 1253286-56-4|English name: Biotin-PEG3-NHS ester|Chinese name: Biotin-PEG3-hydroxy|Molecular weight: 447.6|Molecular formula: C19H33N3O7S

Characteristics: Biotin-PEG3-NHS ester is a biotinylated compound that can be conjugated with a primary amino group (-NH2).The NHS group reacts specifically and efficiently with lysine and N-terminal amino groups at pH 7-9 to form stable amide bonds.

IV. Biotin-PEG3-alcohol

CAS No.: 289714-02-9|English Name: Biotin-PEG3-alcohol|Chinese Name: Biotin-Tripolyethylene Glycol-Bromo|Molecular Weight: 375.5|Molecular Formula: C16H29N3O5S

Characteristics: Biotin-PEG3-alcohol is a biotin-PEG linker containing a biotin group and a terminal primary hydroxyl group (-OH) that reacts with various functional groups

V. Biotin-PEG3-amine

CAS No.: 359860-27-8|English name: Biotin-PEG3-amine|Chinese name: Biotin-PEG3-amine|Molecular weight: 418.6|Molecular formula: C18H34N4O5S

​Characteristics: Biotin-PEG3-amine reacts with NHS esters or carboxylic acids in the presence of EDC or HATU.PEG3 increases the water solubility of molecules conjugated to biotin compounds.