Chondroitin sulfate in vitreous

according to 【1】 Describe the principle of vitreous opacity ：

Chondroitin sulfate (CS) It belongs to glycosaminoglycan (glycosaminoglycans, GAGs) Polysaccharide like

Chondroitin sulfate structure	Proportion （ Total chondroitin sulfate ）
4S	48.8%
0S	37.6%
6S	11.9%
2S6S	1.5%
2S4S	0.3%

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The vitreous contains two chondroitin sulfate proteoglycans , namely IX Type I collagen and versican【2】

Our results show that , The loss of chondroitin sulfate is related to IX There is a strong correlation between the loss of immunogold labeling of collagen type I core protein , The half-life of both is 11 year

MMP23 In human vitreous body fluids 23 It is confirmed that , This enzyme can break IX Type I collagen and causes vitreous liquefaction

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Another basis 【3】

Chondroitin sulfate is used for cartilage growth

Chondroitin, ammonia sugar （ aminoglucose ） Used to inhibit wear

Reference:

【1】Glycosaminoglycans from bovine eye vitreous humour and interaction with collagen type II - PMC

【2】 Age-related changes on the surface of vitreous collagen fibrils

【3】 The difference between chondroitin sulfate and chondroitin aminosugar - Doctor Yun