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玻璃体中的硫酸软骨素
2022-04-23 18:24:00 【微电子学与固体电子学-俞驰】
根据【1】描述的玻璃体混浊的原理：
硫酸软骨素(CS)是属于糖胺聚糖(glycosaminoglycans, GAGs)类的多糖
| 硫酸软骨素结构 | 占比（总硫酸软骨素） |
| 4S | 48.8% |
| 0S | 37.6% |
| 6S | 11.9% |
| 2S6S | 1.5% |
| 2S4S | 0.3% |
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玻璃体含有两种硫酸软骨素蛋白聚糖，即IX型胶原和versican【2】
我们的结果显示，硫酸软骨素的丢失与IX型胶原核心蛋白免疫金标记的丢失之间存在强烈的相关性，两者的半衰期均为11年
MMP23已在人类玻璃体体液23中被证实，这种酶能够破碎IX型胶原并导致玻璃体液化
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另外根据【3】
硫酸软骨素用来软骨增长
氨糖软骨素（氨基葡萄糖）用来抑制磨损
Reference:
【1】Glycosaminoglycans from bovine eye vitreous humour and interaction with collagen type II - PMC
【2】 Age-related changes on the surface of vitreous collagen fibrils
版权声明
本文为[微电子学与固体电子学-俞驰]所创，转载请带上原文链接，感谢
https://yuchi.blog.csdn.net/article/details/124359049
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