Progress in the treatment of depression

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key word ： depression 、 Brain science

Severe depression is a very complex disease , Because of the unclear pathophysiological mechanism, it is impossible to take targeted treatment in clinic . meanwhile , Common treatment methods in the process of clinical treatment, such as electroconvulsive therapy 、 medication 、 Cognitive behavioral therapy and so on have not found the conclusion of stability in the actual effect . Most of the previous imaging meta-analysis results also focused on the brain function of patients with severe depression and healthy groups - Structural changes , It greatly limits us from the perspective of actual treatment effect to find the brain mechanism of the disease .

​ Based on the above questions , We use Activation likelihood estimation（ALE） Meta analysis method for the past 20 Over the years, the treatment results of severe depression based on medical imaging technology have been systematically traced , Provide stable and reliable targets for clinical treatment .

Materials and methods

This study was conducted in PUBMED, SCOPUS, GOOLE SCHOLAR And other platforms use different keyword combinations to preliminarily find 352 Articles , And finally determined after a series of exclusion criteria 53 English Research （ chart 1）.

And then , We extracted the corresponding coordinates and used ALE Statistical methods confirmed the consistency of all literature in the brain region of neuroimaging results . We also studied drug therapy 、 Electroconvulsive therapy 、 Cognitive behavioral therapy and ketamine therapy have significant consistent results in neuroimaging

​ chart 1 Document screening flow chart

result

We are ultimately based on 53 An imaging study （1406 Patients ） The results showed that patients with severe depression showed significant consistency in the brain area of emotion control network after treatment , Including bilateral amygdala / Parahippocampal 、 Bilateral thalamus 、 Right front cinch back / Middle frontal gyrus and right insula / Tabular nucleus （ chart 2）. And for specific therapies , Only electroconvulsive therapy repeatedly found the above parts of the brain , Especially bilateral amygdala and right insula .

​ chart 2 be based on ALE The results obtained by the method are significantly consistent with the results of brain regions

Discussion and conclusion

The results show that there are significant and consistent changes in the brain emotion control network of patients with severe depression after various treatment methods . The affective control network revealed in this study includes cognitive control 、 Emotional processing 、 Reward loop and conscious experience . In especial , The correlation patterns of related brain regions are both traditional “ Pain matrix ” Composition of , There is also stress perception and its prominent attention network , Especially the internal perception component . These findings provide new ideas for us to understand depression and other affective disorders , It provides a potential target for us to evaluate the therapeutic effect or future treatment plan .

Author's brief introduction

Li Changhong

Lecturer of Teacher Education College of Guangdong Second Normal University .2021 year 6 In June, he received a doctor's degree in natural science from Aachen University of technology, Germany . The research direction mainly involves sleep 、 Emotional problems and learning psychology . He has participated in a number of National Natural Science Foundation Projects , stay Human Brain Mapping、Journal of Affective Disorders、Frontiers in Aging Neuroscience And other journals published dozens of articles .

Zhang Delong

Linyi people in Shandong Province , Associate researcher, School of psychology, South China Normal University , Master's Supervisor , South China Normal University - Deputy director of high altitude brain science research center of Tibet University , Part time master tutor of Tibet University .2013 He received a doctorate in basic psychology from South China Normal University ,2016 In, the post doctoral mobile station of Guangzhou University of traditional Chinese medicine came out , On behalf of South China Normal University, he went to Tibet University to aid Tibet , Organization building “ South China Normal University - Plateau brain science research center of Tibet University ”. The research direction involves representation 、 High altitude brain science 、 Mid infrared biological effect 、 Depression, etc , Preside over and participate in general projects of National Natural Science Foundation of China and R & D projects in key fields of Guangdong Province 7 term , Apply for national invention patent 6 term , Invention patent conversion 2 term , Co publishing monographs 2 Ministry , stay Neuroscience bulletin、Brain connectivity、Brain structure and function And other academic journals 50 Yu Wen . He has won the Excellent Doctoral Thesis Award of Guangdong Province and the science and technology award of Tibet Autonomous Region .

original text ：

Li, C., Hu, Q., Zhang, D., Hoffstaedter, F., Bauer, A., & Elmenhorst, D. (2022). Neural correlates of affective control regions induced by common therapeutic strategies in major depressive disorders: an Activation Likelihood Estimation meta-analysis study. Neuroscience & Biobehavioral Reviews, 137.

doi: 10.1016/j.neubiorev.2022.104643

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