Transferrin (TF) Modified Paclitaxel (PTX) Liposomes (TF-PTX-LP) | Transferrin (Tf) Modified Curcumin Liposomes

Transferrin (TF)-modified paclitaxel (PTX) liposomes (TF-PTX-LP)|transferrin (Tf)-modified curcumin liposomes

Transferrin, also known as transferrin, TRF, siderophilin) ​​is the major iron-containing protein in plasma, responsible for transporting iron absorbed by the digestive tract and released by red blood cell degradation.Enter the bone marrow in the form of a complex of TRF-Fe3+ for the production of mature red blood cells.

TRF has a molecular weight of about 77,000 and is a single-chain glycoprotein with a sugar content of about 6%.TRF reversibly binds multivalent ions, including iron, copper, zinc, cobalt, and others.Each molecule of TRF can bind two ferric atoms.TRF is mainly synthesized by hepatocytes and has a half-life of 7 days.The concentration of TRF in plasma is regulated by iron supply. In the state of iron deficiency, plasma TRF concentration rises and returns to normal levels after effective iron treatment.

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